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Comparing Suppository Mold Variability Which Can Lead to Dosage Errors for Suppositories Prepared with the Same or Different Molds

Author(s):  Alexander Kenneth S, Baki Gabriella, Hart Christine, Hejduk Courtney, Chillas Stephanie

Issue:  Nov/Dec 2013 - Volume 17, Number 6
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Abstract:  Suppository molds must be properly calibrated to ensure accurate dosing. There are often slight differences between molds and even in the cavities within a mold. A method is presented for the calibration of standard aluminum 6-, 12-, 50-, or 100 well suppository molds. Ten different molds were tested using water for volume calibration, and cocoa butter for standardization involving establishing the density factor. This method is shown to be straightforward and appropriate for calibrating suppository molds.

Related Keywords: Kenneth S. Alexander, RPh, PhD, Gabriella Baki, Christine Hart, Courtney Hejduk, Stephanie Chillas, suppository mold variability, cocoa butter density variability, theobroma oil, dosage variation

Related Categories: EXCIPIENTS, PEER-REVIEWED, QUALITY CONTROL, DOSAGE FORMS/DRUG CARRIERS

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