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Stability of Captopril in SyrSPend SF

Author(s):  Geiger Christine M,Sorenson Bridget,Whaley Paul A

Issue:  Jul/Aug 2013 - Volume 17, Number 4
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Abstract:  Captopril is an angiotensin-converting enzyme inhibitor available as a tablet. Patients who are unable to take tablets have led compounding pharmacies to seek alternative dosage forms including solutions and suspensions. The objective of this study was to determine the stability of captopril in sorbitol-free, alcohol-free SyrSpend SF suspending agent. The studied samples were compounded into a 0.8-mg/mL suspension and stored in low-actinic plastic bottles at temperatures between 2°C to 8°C. Six samples were assayed at each time point out to 32 days by a stability- indicating high-performance liquid chromatography method. The samples remained within 90% to 110% of the initial concentration throughout day 14 of the study. Based on the data collected, the beyond-use date of these preparations is 14 days when protected from light and refrigerated.

Related Keywords: Christine M. Geiger, MS, Bridget Sorenson, BS, CAPM, Paul A. Whaley, BS, captopril, angiotensin-converting enzyme inhibitor, ACE inhibitor, oral suspension, stability-indicating high-performance liquid chromatography, HPLC, forced degradation studies, storage conditions

Related Categories: EXCIPIENTS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, CARDIOLOGY, STORAGE

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