Download in electronic PDF format for $25



Search the Complete Journal Archives

Treatment of Canine Pulmonary Hypertension: Is Tadalafil an Appropriate Alternative to Sildenafil?

Author(s):  Wung Deanna

Issue:  Jan/Feb 2013 - Volume 17, Number 1
View All Articles in Issue

Abstract:  The drugs tadalafil and sildenafil share the same mechanism. Although more research is necessary to solidify the recommendation of the routine use of tadalafil, human and dog data combined with pharmacokinetic data suggest that dogs may be safely treated for canine pulmonary arterial hypertension with tadalafil for the convenience of less frequent dosing, with effects similar to sildenafil. While more costly, the use of tadalafil has positive implications in improving compliance and, therefore, therapeutic outcomes in canine pulmonary arterial hypertension. This article explores the data for the use of tadalafil in canine pulmonary arterial hypertension and provides example compounded preparations.

Related Keywords: Deanna Wung, dogs, canines, pulmonary artery hypertension, sildenafil, tadalafil, phosphodiesterase type-5 inhibitors, PDE-5 blockers, high pulmonary artery pressure, shortness of breath, breathing difficulties, exercise intolerance, syncope, vasodilation, vasodilator, formulation, adverse effects, pharmacokinetics

Related Categories: FORMULATIONS, VETERINARY, ADVERSE DRUG EVENTS, CARDIOLOGY

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Treatment of Canine Pulmonary Hypertension: Is Tadalafil an Appropriate Alternative to Sildenafil? Wung Deanna Jan/Feb 2013 24-27 Buy
Application of Sildenafil for Pulmonary Hypertension in Canines and Foals Davidson Gigi S Nov/Dec 2006 405-408 Buy
Treating Canine Hepatic Disease Davidson Gigi S May/Jun 2003 188 Buy
Compounded Pimobendan for Canine Chronic Degenerative Mitral Valve Disease and Pulmonary Hypertension Helms Scott R, Fox Samantha, Mixon William, Vail Jane Jan/Feb 2012 34-41 Buy
Diverse Challenges in Pediatric Compounding: Treating Pulmonary Hypertension, Uncombable Hair Syndrome, and Acanthamoeba keratitis Muller George, Young Thomas W, Reina Rachel, Caldwell Delmar R Jan/Feb 2010 40-45 Buy
The Treatment of Canine Atopic Disease Davidson Gigi S May/Jun 2002 210-215 Buy
Sildenafil Citrate 2.5-mg/mL Oral Liquid Allen Loyd V Jr Jul/Aug 2006 306 Buy
Canine Public Servants: Caring for Drug Detection Dogs Davidson Gigi S Sep/Oct 2008 384-390 Buy
Sildenafil 1% Vaginal Cream or Gel Allen Loyd V Jr Mar/Apr 2005 153 Buy
Sildenafil Vaginal Suppository Allen Loyd V Jr Mar/Apr 2005 154 Buy