Download in electronic PDF format for $25



Search the Complete Journal Archives

Stability of Propranolol Hydrochloride in SyrSpend SF

Author(s):  Geiger Christine M, Voudrie Mark A II, Sorenson Bridget

Issue:  Nov/Dec 2012 - Volume 16, Number 6
View All Articles in Issue

Abstract:  Propranolol hydrochloride is a beta blocker used to treat high blood pressure, abnormal heart rhythms, heart disease, pheochromocytoma, and certain types of tremors. Propranolol is marketed by Wyeth (now a part of Pfizer) and AstraZeneca under the brand names Inderal, Inderal LA, Avlocardyl, Deralin, Dociton, Inderalici, InnoPran XL, Sumial, Anaprilium, Bedranol SR (Sandoz). It is also available generically from several manufacturers. Propranolol hydrochloride is available as tablet, capsule, and oral liquid dosage forms in several strengths. Some patients are unable to tolerate oral tablets and capsules, challenging compounding pharmacies to seek alternative dosing options; namely oral solutions and suspensions. The objective of this study was to determine the stability of propranolol hydrochloride in SyrSpend SF. The drug was compounded into a 1-mg/mL suspension using SyrSpend SF and subsequently stored in a low actinic plastic prescription bottle at room temperature conditions. Six samples were assayed at each specific time point extending to 90 days by a stability-indicating high-performance liquid chromatography method. The method was validated for its specificity through forced-degradation studies. Based on the data collected, when protected from light at room temperature, the beyond-use date of propranolol hydrochloride in SyrSpend SF was shown to be at least 90 days.

Related Keywords: Christine M. Geiger, MS, Mark A. Voudrie II, MS, PMP, Bridget Sorenson, BS, CAPM, propranolol hydrochloride, nonselective beta-adrenergic receptor inhibitor, beta blocker, hypertension, high blood pressure, arrhythmias, heart disease, angina, tremor, chest pain, oral suspension, stability

Related Categories: EXCIPIENTS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, CARDIOLOGY, NEUROLOGY, STORAGE

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Stability of Propranolol Hydrochloride in SyrSpend SF Geiger Christine M, Voudrie Mark A II, Sorenson Bridget Nov/Dec 2012 513-515 Buy
Stability of Ursodiol in SyrSpend SF Cherry Flavored Geiger Christine M, Voudrie Mark A II, Sorenson Bridget Nov/Dec 2012 510-512 Buy
Propranolol Hydrochloride 1-mg/mL Injection Allen Loyd V Jr Jul/Aug 2014 330 Buy
Stability of Captopril in SyrSPend SF Geiger Christine M, Sorenson Bridget, Whaley Paul A Jul/Aug 2013 336-338 Buy
Stability of Gabapentin in SyrSpend SF Sorenson Bridget, Voudrie Mark A II, Gehrig Dan Jul/Aug 2012 347-349 Buy
Stability of Omeprazole in SyrSpend SF Alka (Reconstituted) Whaley Paul A, Voudrie Mark A II, Sorenson Bridget Mar/Apr 2012 164-166 Buy
Stability of Verapamil Hydrochloride in SyrSpend SF Compared to Sorbitol Containing Syrup and Suspending Vehicles Voudrie Mark A, Alexander Bridget, Allen D Brett May/Jun 2011 255-258 Buy
Stability of Midazolam in SyrSpend SF and SyrSpend SF Cherry Geiger Christine M, Sorenson Bridget, Whaley Paul A Jul/Aug 2013 344-346 Buy
Stability Assessment of 10 Active Pharmaceutical Ingredients Compounded in SyrSpend SF Geiger Christine M, Sorenson Bridget, Whaley Paul Sep/Oct 2015 420-427 Buy
Propranolol Hydrochloride Capsules Allen Loyd V Jr Nov/Dec 2015 513 Buy