Download in electronic PDF format for $25



Search the Complete Journal Archives

Compounded Pimobendan for Canine Chronic Degenerative Mitral Valve Disease and Pulmonary Hypertension

Author(s):  Helms Scott R, Fox Samantha, Mixon William, Vail Jane

Issue:  Jan/Feb 2012 - Volume 16, Number 1
View All Articles in Issue

Abstract:  Pimobendan (Vetmedin) is an effective treatment for canine chronic degenerative mitral valve disease and dilated cardiomyopathy. In an off-label use, it may also be of benefit for the treatment of pulmonary hypertension in dogs. In this report, we describe the effects of a palatable customized oral form of pimobendan used with both compounded and commercially manufactured conventional drug therapy to treat degenerative mitral valve disease and pulmonary hypertension in two small dogs. For those patients, who resisted many types of oral medication, the standard manufactured dose of pimobendan was inappropriate. Formulations of the preparations used to treat the patients described in this report are provided for easy reference. It should be noted that at the time of this writing, Boehringer Ingelheim GmbH (Ingelheim am Rhein, Germany), the manufacturer of pimobendan, has expressed concern about the stability of that agent in aqueous compounded form. To our knowledge, no current data confirming the stability or bioequivalence of compounded pimobendan exist.

Related Keywords: Scott R. Helms, DVM, Diplomate ABVP, Samantha Fox, BA, CPhT, William Mixon, RPh, MS, FIACP, Jane Vail, canine chronic degenerative mitral valve disease, dilated cardiomyopathy, dogs, phosphodiesterase 3 inhibitor, pimobendan, case reports, enalapril, sildenafil citrate, formulations, furosemide

Related Categories: FORMULATIONS, VETERINARY, CASE REPORTS, CARDIOLOGY, INFORMATION RESOURCES

Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Compounded Pimobendan for Canine Chronic Degenerative Mitral Valve Disease and Pulmonary Hypertension Helms Scott R, Fox Samantha, Mixon William, Vail Jane Jan/Feb 2012 34-41 Buy
Treating Canine Hepatic Disease Davidson Gigi S May/Jun 2003 188 Buy
Transdermal Amlodipine Besylate in Lipoderm for the Treatment of Feline Hypertension: A Report of Two Cases Mixon William, Helms Scott R Sep/Oct 2008 392-397 Buy
The Treatment of Canine Atopic Disease Davidson Gigi S May/Jun 2002 210-215 Buy
Taurine for the Treatment of Canine Dilated Cardiomyopathy Vail Jane Nov/Dec 2006 421-424 Buy
Compounding for Cancer in Companion Animals Mixon William, Northrup Nicole, Vail Jane Jan/Feb 2009 42-49 Buy
Quality Control: Undecided About Buying an In-House Water Purification System? Pros, Cons, and Caveats That May Provide the Answers You Need Mixon William, Fox Samantha, Barnes Danny, Stuart William, Betlach Verne, Hall Richard M, Biller Jeremy, Kelly Russ, Janik Peter, Purcell Julian Nov/Dec 2011 480-487 Buy
Compounding for Pediatric Patients: Case Reports and Formulations Mixon William, Angelle Patricea, Yoch Douglas Jan/Feb 2009 6-12 Buy
Goliath: Case Report on a Canine Case of Epilepsy Ameijeiras Carlos, Ray Jody, Jordan Dinah G, Garcia Abby Furr Jan/Feb 2011 27-31 Buy
Case Report: Clindamycin Hydrochloride 1% Otic Suspension in the Management of Otitis Externa in a Canine Rudner Shara, Pora Amanda, DeMeo Jennifer Mar/Apr 2011 114-116 Buy