Download in electronic PDF format for $25

Kalchem International - Chemicals and Compounding Supplies

Search the Complete Journal Archives

Glutaraldehyde-treated Autologous Pericardium Used in Valve Repairs

Author(s):  McElhiney Linda F

Issue:  Jan/Feb 2012 - Volume 16, Number 1
View All Articles in Issue

Abstract:  In the 1960s and 1970s, mitral valve replacement was the highest risk of all cardiac procedures, with a 20% to 30% mortality rate. Fortunately, there have been major advancements in the procedures for repair or replacement of heart valves. Some of the newer surgical procedures have become far less invasive and hospital stays have been shortened. One of these advancements is the use of autologous pericardium, commonly known as a pericardial patch. Since the procedure uses the patient’s own pericardial tissue, the immune reaction factor is eliminated. The use of a glutaraldehyde soaking technique to strengthen the pericardial tissue in the replacement and repair procedure for mitral valve replacement is discussed in this article. The preparation of the glutaraldehyde soaking solution is a high-risk procedure, and compounding pharmacists play a very important role in properly preparing the glutaraldehyde soaking solution for the cardiovascular surgeon.

Related Keywords: Linda F. McElhiney, PharmD, RPh, FIACP, FASHP, glutaraldehyde soaking solution, autologous pericardium, mitral valve replacement, heart valve disorders, valvular disease, dialdehyde sterilant, formulation


Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Glutaraldehyde-treated Autologous Pericardium Used in Valve Repairs McElhiney Linda F Jan/Feb 2012 12-16 Buy
Compounded Pimobendan for Canine Chronic Degenerative Mitral Valve Disease and Pulmonary Hypertension Helms Scott R, Fox Samantha, Mixon William, Vail Jane Jan/Feb 2012 34-41 Buy
Treating Inner Ear Disorders with Intratympanic Drug Administration McElhiney Linda F Jul/Aug 2011 302-307 Buy
Basics of Compounding for Disorders of the External Ear Allen Loyd V Jr Jan/Feb 2004 46 Buy
I See Colors: Using Vital Dyes in Diagnosing Ophthalmic Disease McElhiney Linda F May/Jun 2012 190-195 Buy
Basics of Compounding for Raynaud's Disease Glasnapp Andrew Jul/Aug 2003 288 Buy
The Treatment of Canine Atopic Disease Davidson Gigi S May/Jun 2002 210-215 Buy
Use of Topical Metronidazole in the Treatment of Anorectal Crohn's Disease McElhiney Linda F Sep/Oct 2013 380-383 Buy
Coenzyme Q10 Supplementation in the Treatment of Heart Disease Bramwell Bethany L Mar/Apr 2010 108-111 Buy
Treating Canine Hepatic Disease Davidson Gigi S May/Jun 2003 188 Buy