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Chemical Stability of Pentoxifylline in a Topical Cream

Author(s):  Gupta Vishnu D

Issue:  Jan/Feb 2012 - Volume 16, Number 1
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Abstract:  The chemical stability of pentoxifylline in a topical cream was studied using a previously reported stability-indicating high-performance liquid chromatographic assay method. The concentrations of the drug were directly related to peak heights. The percent relative standard deviation based on five injections was 0.3. The simple procedure that was developed for the extraction of the drug from the cream has been reported. The excipients present in the commercially available cream base did not interfere with the assay method. The topical cream was stable for at least 62 days when stored in white opaque ointment jars (plastic) at room temperature. The physical appearance of the cream did not change during the study period.

Related Keywords: Vishnu D. Gupta, PhD, pentoxifylline, peripheral vascular disease, peripheral arterial disease, topical preparation, chemical stability, cream base

Related Categories: PACKAGING, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, CARDIOLOGY, DOSAGE FORMS/DRUG CARRIERS, STORAGE

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