Download in electronic PDF format for $35

Search the Complete Journal Archives

Chemical Stability of Pentoxifylline in a Topical Cream

Author(s):  Gupta Vishnu D

Issue:  Jan/Feb 2012 - Volume 16, Number 1
View All Articles in Issue

Abstract:  The chemical stability of pentoxifylline in a topical cream was studied using a previously reported stability-indicating high-performance liquid chromatographic assay method. The concentrations of the drug were directly related to peak heights. The percent relative standard deviation based on five injections was 0.3. The simple procedure that was developed for the extraction of the drug from the cream has been reported. The excipients present in the commercially available cream base did not interfere with the assay method. The topical cream was stable for at least 62 days when stored in white opaque ointment jars (plastic) at room temperature. The physical appearance of the cream did not change during the study period.

Related Keywords: Vishnu D. Gupta, PhD, pentoxifylline, peripheral vascular disease, peripheral arterial disease, topical preparation, chemical stability, cream base


Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Chemical Stability of Pentoxifylline in a Topical Cream Gupta Vishnu D Jan/Feb 2012 80-81 Buy
The Treatment of Canine Atopic Disease Davidson Gigi S May/Jun 2002 210-215 Buy
Basics of Compounding for Raynaud's Disease Glasnapp Andrew Jul/Aug 2003 288 Buy
Treating Canine Hepatic Disease Davidson Gigi S May/Jun 2003 188 Buy
Current Topical Treatments in Wound Healing - Part 1 Helmke Christopher D Jul/Aug 2004 269 Buy
Chemical Stability of Brompheniramine Maleate in an Oral Liquid Dosage Form Gupta Vishnu D, Gupta Vikas S Jan/Feb 2011 78-80 Buy
Use of Topical Metronidazole in the Treatment of Anorectal Crohn's Disease McElhiney Linda F Sep/Oct 2013 380-383 Buy
Pentoxifylline 5% in Dermabase Allen Loyd V Jr Jul/Aug 2018 324 Buy
Pentoxifylline 20-mg/mL Oral Suspension Allen Loyd V Jr Jan/Feb 2008 70 Buy
Topical Oil-in-Water Cream Bases, Featured Excipient: Allen Loyd V Jr Jul/Aug 2002 303-304 Buy