Download in electronic PDF format for $25

Kalchem International - Chemicals and Compounding Supplies

Search the Complete Journal Archives

Stability of Methimazole in Poloxamer Lecithin Organogel to Determine Beyond-Use Date

Author(s):  Pignato Alyssa, Pankaskie Marvin, Birnie Christine

Issue:  Nov/Dec 2010 - Volume 14, Number 6
View All Articles in Issue

Abstract:  The purpose of this stability study was to determine the beyond-use date of the active ingredient methimazole extemporaneously prepared for transdermal absorption to treat feline hyperthyroidism. The methimazole was prepared in poloxamer lecithin organogel and subjected to a three-month stability study. It was determined that under room temperature conditions (25°C ± 2°/60% RH ± 5%) the methimazole concentration remained above 90% after 62 days. An accelerated condition of 35°C and refrigerated condition of 5°C were also employed to see how temperature affected the stability of the drug. Under all three conditions the methimazole concentration dropped below 90% after day 62. It was observed that the refrigerated conditions appeared to be least stable both physically and chemically. A control sample was also prepared, stored, and packaged similarly to the sample preparations. As a result, the beyond-use date was determined to be 60 days at room temperature. The drug preparation should not be stored in a refrigerated condition.

Related Keywords: Alyssa Pignato, BS, Marvin Pankaskie, PhD, Christine Birnie, RPh, PhD, methimazole, topical preparation, transdermal administration, feline, cat, hyperthyroidism, stability, storage conditions, temperature, formulation


Printer-Friendly Version

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Stability of Methimazole in Poloxamer Lecithin Organogel to Determine Beyond-Use Date Pignato Alyssa, Pankaskie Marvin, Birnie Christine Nov/Dec 2010 522-525 Buy
Veterinary Transdermal Medications: A to Z Davidson Gigi S Mar/Apr 2003 106 Buy
Transdermal Methimazole in the Treatment of 16 Cats with Hyperthyroidism Wingate Gary Sep/Oct 2002 344 Buy
Five Compounds for Treating Diabetes-Related Conditions Meece Jerry May/Jun 2003 170 Buy
Understanding Feline Hyperthyroidism Davidson Gigi S Sep/Oct 2003 345 Buy
Rapid-Dissolve Technology: An Interview With Loyd V. Allen, Jr., PhD, RPh Allen Loyd V Jr Nov/Dec 2003 449-450 Buy
Transdermal Amlodipine Besylate in Lipoderm for the Treatment of Feline Hypertension: A Report of Two Cases Mixon William, Helms Scott R Sep/Oct 2008 392-397 Buy
Preparation and In Vitro Evaluation of a Pluronic Lecithin Organogel Containing Ricinoleic Acid for Transdermal Delivery Boddu Sai HS, Bonam Sindhu Prabha, Wei Yangjie, Alexander Kenneth May/Jun 2014 256-261 Buy
Compounding Transdermal Medication for Feline Patients Eichstadt Lauren R Jul/Aug 2016 271-274 Buy
Absorption of Transdermal Fluoxetine Compounded in a Lipoderm Base Compared to Oral Fluoxetine in Client-owned Cats Eichstadt Lauren R, Corriveau Lorraine A, Moore George E, Knipp Gregory T, Cooper Bruce R, Gwin Wilson E May/Jun 2017 242-246 Buy